Process for purification and concentration of gammaretroviral vectors established under GMP

The downstream processing of viral vector particles for gene therapy is becoming a critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to develop compliant as well as cost-efficient processes and the demand for higher purities has brought forward new downstream trains.

EUFETS has established an efficient and robust down-stream process to purify and concentrate gammaretroviral vectors while ensuring high recoveries.